Dedicated to supplying the biomedical research community with the highest quality complement reagents.

our products

Factor Ba

Product Description

Factor Ba is the fragment of complement factor B that results from activation of the alternative pathway. CompTech prepares the factor Ba fragment from factor B which was purified from normal human serum. Complement factor B is a glycosylated protein composed of a single 93,000 Da polypeptide chain. Factor B is an essential component of the alternative pathway of complement activation and is found in plasma at approximately 200 µg/mL. In the presence of Mg++ factor B binds to C3b and the C3b,B complex can be activated by factor D, a serine protease that circulates as an active trypsin-like serine protease. Cleavage of factor B by factor D causes the release of the Ba fragment (33,000 Da) and leaves the 60,000 Bb fragment bound to C3b. This Ba fragment comes from the N-terminal of factor B and it contains three CCP domains which interact with C3b (Morley, B.J. and Walport, M.J. (2000)). The isolated fragment Ba has been reported to have a weak affinity for C3b and to inhibit the interaction of factor B with C3b thus inhibiting the activation of the alternative pathway (Pryzdial, E.L. and Isenman, D.E., (1987)).

The fragments of factor B (Ba and Bb) have been proposed to elicit several biological responses. See the section titled Function below and in the product description for the Bb fragment.

(For full product description see link...)

Catalog #:
Sizes Available:
100 µg/vial
1.0 mg/ml