Factor D-Dpl is normal human serum depleted of factor D by immunoaffinity chromatography. The product is tested for the absence of factor D by functional assays for alternative pathway activity and by immunodiffusion against anti-factor D. Factor D-Dpl is certified to possess a functional alternative pathway for complement activation after reconstitution with 2 µg factor D/mL (Morgan, B.P. (2000); Dodds, A.W. and Sim, R.B. (1997)). It is tested for and certified to contain functional classical pathway indicating that all other complement components necessary for classical and alternative pathway activation are present except for factor D. Lectin pathway activity is not routinely tested or certified, but it would be expected to be active.
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