Cyno C1q-Dpl (USA Only)

Product Description

Normal cynomolgus monkey (Macaca fascicularis) serum (Cat# NCYS) was depleted of C1q by ion exchange and immunoaffinity chromatography.  The product is tested for the absence of C1q by functional assays for classical pathway activity and for C1q protein by double immunodiffusion. Cyno C1q-Dpl is certified to possess a functional alternative pathway for complement activation (Morgan, B.P. (2000); Dodds, A.W. and Sim, R.B. (1997)). Addition of purified cyno C1q protein (70 µg/mL) to cyno C1q-Dpl resulted in partial restoration of the classical pathway (< 50% CH50 activity) when compared to NCYS as complement standard (See Assays Section for details). The absence of C1q does not prevent complement activation by the lectin and alternative pathways on appropriate surfaces.

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