Normal human serum depleted of complement C5 protein by immunoaffinity chromatography. The product is tested for the absence of C5 by functional assays for classical pathway activity and alternative pathway activity and for C5 protein by double immunodiffusion. C5-Dpl is certified to possess functional classical and alternative pathways for complement activation up to the step of C5 activation (Law, S.K.A. and Reid, K.B.M. (1995); Morgan, B.P. ed. (2000); Dodds, A.W. and Sim, R.B. editors (1997)). Functional complement systems can be reconstituted by addition of purified C5 protein (75 µg/mL) indicating that all other complement components necessary for complement activation are present.
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