Normal human serum depleted of complement C2 protein by immunoaffinity chromatography. The product is tested for the absence of C2 by functional assays for classical pathway activity and for C2 protein by double immunodiffusion. C2-Dpl is certified to possess a functional alternative pathway for complement activation (Morgan, B.P. (2000); Dodds, A.W. and Sim, R.B. (1997)). A functional classical pathway can be reconstituted by addition of purified C2 protein (25 µg/mL) indicating that all other complement components necessary for classical pathway activation are present. The absence of C2 also prevents complement activation by the lectin pathway but the alternative pathway will still activate on appropriate surfaces.
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