Natural human C4a is prepared by cleavage of human C4 protein by human C1s. It is produced during activation of both the classical and lectin pathways of complement. C4a is a member of the anaphylatoxin family of three proteins (C3a, C4a and C5a) produced by the activation of complement (Hugli, T.E. et al. (1981)). Removal of the C-terminal arginine by serum carboxypeptidase N (Meuller-Ortiz, S.L., et al. (2009)) yields C4a desArg and destroys all biological activities of C4a. C4a desArg is an unglycosylated polypeptide containing 76 amino acids with a molecular mass of 8,603 daltons.
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